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ACTIVE NOT RECRUITING
NCT04984811
PHASE2

NT-I7 in Combination With Atezolizumab in Previously Untreated, PD-L1-expressing, Locally Advanced or Metastatic NSCLC

Sponsor: NeoImmuneTech

View on ClinicalTrials.gov

Summary

This is a multicenter, open-label, single-arm Phase II study to evaluate anti-tumor efficacy and safety of NT-I7 in combination with atezolizumab in subjects with PD-L1-expressing (TPS ≥ 1%), metastatic (Stage IV) or locally advanced squamous or non-squamous NSCLC who have not received prior systemic therapy in the metastatic or locally advanced setting. Eligible subjects must have measurable disease according to RECIST 1.1. This Phase II study will enroll up to 83 subjects.

Official title: A Multicenter, Open-label, Single-arm Phase II Study to Evaluate Anti-tumor Efficacy and Safety of NT-I7 in Combination With Atezolizumab in Subjects With Previously Untreated, PD-L1-expressing, Locally Advanced or Metastatic NSCLC

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

83

Start Date

2021-11-03

Completion Date

2025-03

Last Updated

2024-03-05

Healthy Volunteers

No

Interventions

DRUG

efineptakin alfa

1200 μg/kg NT-I7 administered intramuscularly (IM) once every 6 weeks (Q6W) starting on Cycle 1. The treatment will be continued up to a maximum of 35 cycles (approximately 2 years).

DRUG

Atezolizumab

1200 mg atezolizumab administered intravenously (IV) once every 3 weeks (Q3W) starting on Cycle 1. The treatment will be continued up to a maximum of 35 cycles (approximately 2 years).

Locations (22)

University of South Alabama

Mobile, Alabama, United States

TOI Clinical Research

Cerritos, California, United States

Eastern CT Hematology & Oncology Associates

Norwich, Connecticut, United States

Florida Cancer Specialists - South Research Office

Fort Myers, Florida, United States

BRCR Medical Center

Plantation, Florida, United States

Florida Cancer Specialists - North Research Office

St. Petersburg, Florida, United States

Florida Cancer Specialists - East Research Office

West Palm Beach, Florida, United States

University Cancer and Blood Center

Athens, Georgia, United States

Goshen Center for Cancer Care

Goshen, Indiana, United States

Norton Cancer Institute

Louisville, Kentucky, United States

Pikeville Medical Center, Inc.

Pikeville, Kentucky, United States

MaineHealth Cancer Care

South Portland, Maine, United States

TidalHealth Peninsula Regional, Inc.

Salisbury, Maryland, United States

Summit Health Medical Center

Florham Park, New Jersey, United States

East Carolina University

Greenville, North Carolina, United States

Zangmeister Cancer Center

Columbus, Ohio, United States

OHSU Knight Cancer Institute

Portland, Oregon, United States

Tennessee Oncology - Chattanooga

Chattanooga, Tennessee, United States

Thompson Cancer Survival Center

Knoxville, Tennessee, United States

Tennessee Oncology - Nashville

Nashville, Tennessee, United States

Renovatio Clinical - El Paso

El Paso, Texas, United States

Renovatio Clinical - The Woodlands

The Woodlands, Texas, United States