Clinical Research Directory

Inclusion Criteria: * Ability to provide informed consent before any trial-related activities * History of any malignancy * Completion of cancer-directed therapy (e.g., surgery, chemotherapy, and radiotherapy) prior to enrollment (patients receiving ongoing endocrine or targeted therapy are eligible to participate) * No evidence of residual or recurrent cancer under active treatment * Age ≥18 years * Body mass index (BMI) ≥30 kg/m2 or BMI ≥27 kg/m2 with one or more treated or untreated weight-related coexisting conditions * Willing to be randomized * Allow the collection and storage of biospecimens and data for future use Exclusion Criteria: * Engaging in ≥3 purposeful exercise sessions per week, on average, over the past 12 weeks * Significant purposeful weight loss (\>11 kg) within the past 12 weeks * Current use of medications or devices for the purpose of weight loss * Metabolic or bariatric surgery within the last year * Cardiovascular, respiratory, or musculoskeletal disease that would prohibit participation in an exercise and weight loss program * Currently pregnant, breastfeeding, or planning to become pregnant with the next 12 weeks * Psychiatric disorders or conditions that would preclude participation in the study intervention * Any other condition which, in the opinion of the investigator, may impede testing of the study hypothesis or make it unsafe to engage in the study