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NASH AMPK Exercise Dosing (AMPED) Trial
Sponsor: Milton S. Hershey Medical Center
Summary
There is no known cure or regulatory agency approved drug therapy for nonalcoholic fatty liver disease (NAFLD), the leading cause of liver disease worldwide, and its progressive type, NASH. This places increased importance on using exercise to treat NAFLD. While physical activity is recommended for all with NAFLD, how to best prescribe exercise as a specific treatment remains unknown, including what dose of exercise is most effective.
Key Details
Gender
All
Age Range
18 Years - 69 Years
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2022-08-30
Completion Date
2026-07-15
Last Updated
2025-10-14
Healthy Volunteers
No
Conditions
Interventions
Exercise
Aerobic exercise can be completed by walking, jogging or running or by using cardio equipment (e.g., recumbent bike). Each session will begin with a warm-up with walking (30-40% target HR for 5-min) and dynamic exercises (knee-to-chest, 10-yd lateral shuffle, bent over twist, calf sweeps, leg swings). A 5-min walking cool down will end the session (30-40% target HR).
Locations (1)
Penn State Hershey Medical Center
Hershey, Pennsylvania, United States