Clinical Research Directory

Inclusion criteria 1. 20≤Age\<70 2. undergone neoadjuvant chemotherapy 3. HER-2 or triple negative breast cancer 4. clinical stage T1-3, N0-1, M0 (AJCC 8th) 5. not Inflammatory breast cancer 6. neoadjuvant chemotherapy should be done before surgery(sandwich method is not allowed) * least four times anthacycline or taxane-based regimens * no axilla lesion progression during chemotherapy * no period of adverse response during chemotherapy 7. undergone anti HER-2 therapy in HER-2 positive patient 8. no preoperative anti hormonal therapy 9. no preoperative radiation therapy 10. did not axillary lymph node biopsy before neoadjuvant chemotherapy 11. physical examination expected complete remission. And radiological expected Tumor size ≤ 2cm or non-mass enhancement ≤ 4cm 12. no previous axilla surgery 13. no previous ipsilateral breast surgery for invasive cancer 14. no Pregnancy-associated breast cancer 15. ECOG performance status 0-1 16. Serum or urine b-HCG negative 17. agree to the consent form Exclusion criteria 1. During pregnancy 2. major depression or taking psychiatric medication 3. significant psychiatric disorder or history of taking antipsychotic drugs 4. any other lymph node metastasis than axillary lesion 5. undergoing total mastectomy 6. do not agree to the consent form