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Evaluation of Lung T1-MRI in Pediatric Cystic Fibrosis Patients
Sponsor: University Hospitals Cleveland Medical Center
Summary
In this observational study, the investigators evaluate the sensitivity of T1-MRI to identify lung perfusion changes in pediatric patients with CF (age = 6-11) before and after initiating FDA-approved Trikafta therapy. The investigators compare these Lung T1 MRI assessments (% Normal lung perfusion) to currently best-available assessments of lung function in CF patients (i.e., MBW (LCI( and Spirometry (FEV1 % Predicted).
Official title: Lung T1 MRI Assessments of Children With CF Initiating Trikafta Therapy
Key Details
Gender
All
Age Range
5 Years - 11 Years
Study Type
OBSERVATIONAL
Enrollment
48
Start Date
2020-12-15
Completion Date
2023-12-15
Last Updated
2026-09-14
Healthy Volunteers
No
Conditions
Interventions
Lung T1 MRI
Evaluation of lung T1 MRI to Assess Lung Disease
Locations (3)
Riley Hospital for Children
Indianapolis, Indiana, United States
CS Mott Children's Hospital
Ann Arbor, Michigan, United States
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States