Clinical Research Directory

Inclusion Criteria: * Patient ≥ 18 years old, * Patient to be operated in first intention of a sleeve gastrectomy * Initial BMI between 35Kg/m² and 40 Kg/m² associated with at least one severe comorbidity likely to be improved after surgery according to HAS recommendations. OR initial BMI ≥ 40 Kg/m². * Multidisciplinary follow-up of at least 6 months before surgery * Validation of the surgical intervention in a multidisciplinary consultation meeting * Certificate of no contraindication by a psychiatrist * Patient who has the capacity to understand the protocol and has given consent to participate in the research, * Patient with social security coverage. Exclusion Criteria: * Eating disorder or mental disorder * Misunderstanding of the protocol * Psychiatric contraindication * Initial BMI \<35Kg/m². * Initial BMI between 35Kg/m² and 40 Kg/m² without comorbidities. * Esophagitis of grade B and above on the Oeso-Gastro-Duodenal Fibroscopy * CARLSSON score (score ≥ 4) preoperatively * Presence of a Proton-Pump Inhibitors treatment * Patient to have a 2-stage surgery (first sleeve gastrectomy then gastric bypass or Single Anastomosis Duodeno-Ileal bypass) * Patient participating in another interventional clinical research protocol involving a drug or medical device * Patient who are pregnant, breastfeeding, or who have the potential to become pregnant without effective contraception at the time of inclusion and up to 24 months after surgery * Patient under guardianship, curators or legal protection,P