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Systemic Sclerosis and Innate T Cells
Sponsor: Poitiers University Hospital
Summary
Innate T cells (ITC) are decreased in systemic sclerosis (SS) and an early lymphocyte innateness has been reported. In the other part, ITC are implicated on inflammatory process, including the IL-33/ST2 axis, which is also involved in ScS endotheliopathy. Data are however scarce and physiopathological mechanisms have not been assessed to date. The investigators hypothesize a global lymphocyte innateness in SSc, linked to a chronic ITC stimulation by innate signals leading to ITC exhaustion, and their potential role in endotheliopathy and fibroblast activation in SSc.
Official title: Role of Innate T Cells in Physiopathology of Systemic Sclerosis
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
235
Start Date
2022-02-28
Completion Date
2025-12-17
Last Updated
2026-05-22
Healthy Volunteers
Yes
Conditions
Interventions
Blood test
Unique blood draw of 45mL for all the participants
Locations (1)
CHU poitiers
Poitiers, France