Clinical Research Directory

Inclusion Criteria: 1. 21-60 years of age 2. Able to provide consent 3. Heavy drinker, defined as: for men, consuming more than 4 drinks on any day or more than 14 drinks per week OR, for women, consuming more than 3 drinks on any day or more than 7 drinks per week over the last 3 months. 4. Regular legal-market cannabis smoker, defined as using smoked flower cannabis obtained from a dispensary at least 3 days per/week over the past 3 months 5. Willing to abstain from cannabis use for 14 days 6. We are prioritizing the recruitment of participants in the Fort Collins/Loveland area Exclusion Criteria: 1. Daily tobacco use\*\*\* (Vape and Hooka included) 2. Actively seeking treatment for alcohol use disorder or other substance use disorder 3. Females cannot be pregnant, breastfeeding or trying to become pregnant 4. Meet criteria for psychotic, bipolar or major depressive disorder with suicidal ideation, or history of these disorders 5. Immune-relevant disease (e.g., osteoarthritis, HIV, cancer, recent infection, other autoimmune disorder) or currently taking an immune-modulating medication\*\*\* 6. Current use of psychotropic medications (except anti-depressants ) 7. Report illicit drug use in past 60-days or fail drug screen 8. Major medical condition that contraindicates the consumption of alcohol or cannabis. 9. Use of an antibiotic medication in the past 3 months 10. Current GI disorder including: inflammatory bowel disease, irritable bowel disease, diverticular disease, peptic ulcer/gastritis and gastroesophageal reflux disease. 11. Use of probiotic or supplement drinks at least once per week over the last 3 months