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Restricted or Liberal Antibiotics After Appendectomy - Denver Health
Sponsor: Denver Health and Hospital Authority
Summary
The purpose of this study is to see if decreasing the amount of antibiotics after appendicitis surgery can decrease the risk of adverse effects associated with antibiotics while at the same time ensuring participant safety.
Official title: Complex And Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) Using Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR): A Randomized Controlled Trial at Denver Health
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
657
Start Date
2021-11-01
Completion Date
2025-07-16
Last Updated
2026-06-30
Healthy Volunteers
No
Conditions
Interventions
Restricted Duration of SOC Antibiotic Use
Standard of Care Antibiotic use will be restricted to none or up to 24 hours of post-operative antibiotics.
Liberal Duration of SOC Antibiotic Use
Standard of Care Antibiotic use will be permitted for 24 hours or up to 4 days of post-operative antibiotics.
Locations (1)
Denver Health and Hospital Authority
Denver, Colorado, United States