Clinical Research Directory

Inclusion Criteria: 1. Patient is on ECMO and expected to remain on ECMO for at least 24 hours 2. Patient is aged 18 years or older. 3. Patient was functionally independent prior to the current admission. 4. Patient is eligible for Medicare (Australian sites only). Exclusion Criteria: 1. Patient has been receiving ECMO for more than 72 hours. 2. Patient has been in ICU for more than 5 days. 3. Patient has suspected or proven primary myopathic or neurological process associated with prolonged weakness or acute brain injury. 4. Death is deemed imminent by the treating clinician. 5. Patient has a documented medical diagnosis of cognitive impairment e.g. dementia. 6. Patient was unable to mobilise prior to this admission. 7. Patient is unable to communicate in local language. 8. Patient is known to be pregnant. 9. Patient is unlikely to be contactable for 6 months follow-up, e.g. overseas resident, incarcerated 10. The treating clinician does not believe it is in the best interests of the patient to participate in the study 11. Patient who has a bidirectional cannula in situ