Clinical Research Directory

Inclusion Criteria: 1. Any gender; male or female; aged 18- 75 years old. 2. Severe alcoholic hepatitis defined as 2.1 Onset of jaundice within prior 8 weeks. 2.2 Ongoing alcohol consumption of \>40 g/day (3 drinks) in females or \>60 g/day (4 drinks) in males for 6 months or more, with less than 60 days of abstinence before the onset of jaundice. 2.3 Aspartate aminotransferase \>50, Aspartate aminotransferase/Alanine aminotransferase ratio \> 1.5, BUT both values \<400 IU/L. 2.4 Serum total bilirubin \>3.0 mg/dl. 2.5 MELD score \>15 and/or Maddrey DF score of ≥32. Exclusion Criteria: 1. Non-alcoholic related liver diseases. 2. Patients with swallowing dysfunction at risk of aspiration. 3. Patients at risk for or with known anatomic or functional gastrointestinal (GI) obstruction or who have undergone major intra-abdominal surgery in the last year. 4. Patients who have undergone placement of a portosystemic shunt, infection of which may require prolonged antibiotics. 5. Patients with any congenital or acquired immunodeficiency (Other than liver disease) 6. Uncontrolled infections, sepsis, or GI bleeding. 7. Presence of cancer especially patients with skin cancer who is receiving or may receive systemic chemotherapy or immunotherapy during the study period. 8. Underlying disease that might be exacerbated by proposed treatments (e.g. HCV, HBV, HIV, TB). 9. Serum creatinine \>2.5 mg/dl at presentation. 10. Pregnant and breastfeeding patients. 11. Active use drug addiction. 12. PI thinks their participation would pose a health risk e.g. patients with very severe AH with MELD score \>30 or Maddrey DF \> 60 or patient will be getting liver transplantation imminently. 13. Any other major illness/ condition that in the investigators judgment, will substantially increase the risk to the participant.