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Comparison Neuromuscular Blockade Monitors
Sponsor: University of Washington
Summary
The overall objective of this research is to evaluate different laboratory-built and commercially available sensors used to measure the effects of neuromuscular blocking drugs on neuromuscular function during surgery, by measuring evoked thumb twitch response to ulnar nerve stimulation (also known as "twitch monitoring"). The specific aim is to compare mechanomyography, which is the "gold standard" laboratory measurement to assess neuromuscular blockade, to the sensors used in commercially available neuromuscular blockade monitors, such as acceleromyography and electromyography. The study endpoints are the train-of-four count (TOFC), the ratio of the height of the 4th twitch to the height of the 1st twitch (train-of-four ratio, TOFR), and the post tetanic count (PTC). The mechanomyography devices have been constructed in our laboratory and are not commercially available.
Official title: Comparative Assessment of Neuromuscular Blockade Monitors
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
51
Start Date
2022-02-01
Completion Date
2024-12-01
Last Updated
2026-07-08
Healthy Volunteers
No
Conditions
Interventions
Mechanomyograph Twitch Monitor
Measurement of train-of-four count and ratio and post tetanic count
Stimpod Twitch Monitor
Measurement of train-of-four count and ratio and post tetanic count
TetraGraph Twitch Monitor
Measurement of train-of-four count and ratio and post titanic count
TwitchView Twitch Monitor
Measurement of train-of-four count and ratio and post tetanic count
Nihon Kohden Twitch Monitor
Measurement of train-of-four count and ratio and post tetanic count
Palpation of twitch count
The train-of-four count is determined by manual palpation of the evoked twitch response
Locations (1)
University of Washington Medical Center
Seattle, Washington, United States