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Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Sponsor: Petter Bjornstad
Summary
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death. Youth-onset T2D typically manifests during or shortly after puberty in adolescents with obesity. Epidemiological data implicate puberty as an accelerator of kidney disease in youth with obesity and diabetes and the investigators posit that the link between puberty and T2D-onset may explain the high burden of DKD in youth-onset T2D. A better understanding of the impact of puberty on kidney health is needed to promote preservation of native kidney function, especially in youth with T2D.
Official title: PANTHER Study: Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress
Key Details
Gender
All
Age Range
8 Years - 14 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2021-09-27
Completion Date
2027-12-01
Last Updated
2025-03-24
Healthy Volunteers
Yes
Conditions
Interventions
Aminohippurate Sodium Inj 20%
Diagnostic aid/agent used to measure effective renal plasma flow (ERPF)
Iohexol Inj 300 MG/ML
Diagnostic aid/agent used to measure glomerular filtration rate (GFR)
Dextran 40
Diagnostic aid/agent used to measure glomerular size and selectivity
Locations (2)
Children's Hospital Colorado
Aurora, Colorado, United States
Seattle Children's Hospital
Seattle, Washington, United States