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Cortical Contributions to Frequency Following Responses and Modulation
Sponsor: Northwestern University
Summary
The frequency-following response (FFR), a scalp-recorded neurophonic potential, is a widely used metric of speech encoding integrity in healthy and clinical human populations. The translational potential of the FFR as a biomarker is constrained by poor understanding of its neural generators and influencing factors. This study leverages a cross-species and cross-level approach to provide mechanistic insight into the properties of the cortical source of the FFR, and elucidate the role of cortical feedback via cortico-collicular projections on modulation of the FFR as a function of stimulus context, arousal state, and category relevance. This clinical trial will focus on the influences of category relevance, predictability, and participant arousal state on the FFRs in neurotypical human participants.
Key Details
Gender
All
Age Range
13 Years - 25 Years
Study Type
INTERVENTIONAL
Enrollment
70
Start Date
2022-01-20
Completion Date
2026-01-20
Last Updated
2024-05-31
Healthy Volunteers
Yes
Conditions
Interventions
Speech and non-speech sound stimulation
Listening to repetitive and extended sound presentation induces specific neural and physiological activity that we will measure via electroencephalography and pupillometry
Locations (1)
Northwestern University
Evanston, Illinois, United States