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RECRUITING
NCT05014165

Backtracking Leukemia-Typical Somatic Mutations in Cord Blood

Sponsor: Children's Oncology Group

View on ClinicalTrials.gov

Summary

A comprehensive mechanistic and epidemiological study to obtain banked cord blood samples from consecutive childhood leukemia patients enrolled in the COG Project:EveryChild (APEC14B1) study. Will attempt to backtrack the initiating genomic alteration identified in the matched diagnostic leukemia sample and molecularly characterize pre-leukemic cells. The ultimate goal of this research is to pinpoint the cell of origin of leukemogenic alterations formed in utero, elucidating the etiology of these initiating mutations (as opposed to frank leukemia), and devising a test for circulating pre-leukemia that can be applied on a population-wide basis.

Key Details

Gender

All

Age Range

Any - 25 Years

Study Type

OBSERVATIONAL

Enrollment

300

Start Date

2021-08-25

Completion Date

2026-09-30

Last Updated

2026-04-08

Healthy Volunteers

No

Interventions

OTHER

Cord blood Sample Collection

Obtain banked cord blood samples from consecutive childhood leukemia patients

OTHER

Case identification and recruitment

Cases meeting eligibility and who have given consent through APEC14B1 for future contact for non-therapeutic studies

OTHER

Questionnaire Administration

The family will be given an option to complete questionnaire on paper, online, or over the telephone.

Locations (1)

University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, United States