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Backtracking Leukemia-Typical Somatic Mutations in Cord Blood
Sponsor: Children's Oncology Group
Summary
A comprehensive mechanistic and epidemiological study to obtain banked cord blood samples from consecutive childhood leukemia patients enrolled in the COG Project:EveryChild (APEC14B1) study. Will attempt to backtrack the initiating genomic alteration identified in the matched diagnostic leukemia sample and molecularly characterize pre-leukemic cells. The ultimate goal of this research is to pinpoint the cell of origin of leukemogenic alterations formed in utero, elucidating the etiology of these initiating mutations (as opposed to frank leukemia), and devising a test for circulating pre-leukemia that can be applied on a population-wide basis.
Key Details
Gender
All
Age Range
Any - 25 Years
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2021-08-25
Completion Date
2026-09-30
Last Updated
2026-04-08
Healthy Volunteers
No
Interventions
Cord blood Sample Collection
Obtain banked cord blood samples from consecutive childhood leukemia patients
Case identification and recruitment
Cases meeting eligibility and who have given consent through APEC14B1 for future contact for non-therapeutic studies
Questionnaire Administration
The family will be given an option to complete questionnaire on paper, online, or over the telephone.
Locations (1)
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, United States