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Conduction System Pacing With Left Bundle Branch Pacing as Compared to Standard Right Ventricular Pacing
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre
Summary
High burden right ventricular (RV) pacing has been shown to increase cardiovascular mortality, incidence of heart failure (HF), worsen left ventricular (LV) function and accelerate the development of atrial fibrillation (AF). High percentage ventricular pacing and wider paced QRS in the setting of normal baseline LV ejection fractions have consistently been shown to be independent risk factors for pacing-induced cardiomyopathy. Left bundle branch pacing (LBBP) has emerged as a potential alternative pacing mechanism that may avoid LV dyssynchrony and pacing-induced LV dysfunction by mimicking native electrical conduction.
Official title: LEFT Bundle Pacing vs Standard Right Ventricular Pacing for Heart Failure
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1300
Start Date
2022-09-01
Completion Date
2030-01-01
Last Updated
2026-03-11
Healthy Volunteers
No
Conditions
Interventions
Left bundle branch pacing lead
Implantation of a left bundle branch pacing lead via sheath, to perform selective or non-selective pacing
Right ventricular active fixation lead
Active fixation lead (standard)
Locations (1)
McGill University Health Centre-Research Institute
Montreal, Quebec, Canada