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Dexamethasone in Total Knee Arthroplasty
Sponsor: Rush University Medical Center
Summary
The purpose of this study is to determine the most efficacious and safest dexamethasone dose given intraoperatively during total knee arthroplasty that reduces postoperative opioid consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications.
Official title: Dexamethasone in Total Knee Arthroplasty: What Dose Should we be Giving Patients Intraoperatively
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
438
Start Date
2021-10-28
Completion Date
2025-05-30
Last Updated
2026-08-03
Healthy Volunteers
Yes
Conditions
Interventions
Dexamethasone 4mg
4mg intravenous dexamethasone, administered shortly after induction of anesthesia
Dexamethasone 8 Mg/mL Injectable Suspension
8mg intravenous dexamethasone, administered shortly after induction of anesthesia
Dexamethasone 16mg
16mg intravenous dexamethasone, administered shortly after induction of anesthesia
Locations (10)
Stanford University
Redwood City, California, United States
University of California, San Francisco
San Francisco, California, United States
Rush University medical Center
Chicago, Illinois, United States
Mass General Brigham
Somerville, Massachusetts, United States
Mayo Clinic Institutional Review
Rochester, Minnesota, United States
Washington University
St Louis, Missouri, United States
NYU Langone Health
New York, New York, United States
Columbia University Irving Medical Center
New York, New York, United States
University of Pennsylvania Perelman School of Medicine
Philadelphia, Pennsylvania, United States
Jefferson Philadelphia University and Thomas Jefferson University
Philadelphia, Pennsylvania, United States