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HA35 Moderate Alcoholic Hepatitis (AH) Study
Sponsor: The Cleveland Clinic
Summary
Eligible participants will be asked to take a placebo/treatment capsule for 90 days and participate in two in-person study visits, one at the start of the 90 days and the second at the completion of study supplement administration. Both visits will include a physical exam, clinical labs, body composition measurements, muscle strength tests, questionnaires, and urine and stool collections. Additionally, a sugar cocktail will be consumed to measure gut permeability and a muscle biopsy will be collected. The day after the visits, you will need to return to drop off the 24-hour urine collection. Two phone visits will be performed in between the in-person visits at day 30 and 60 where you will be asked a series of questionnaires as well as asked about study supplement compliance.
Official title: Mechanism of HA35 in Patients With Alcoholic Liver Disease
Key Details
Gender
All
Age Range
21 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
54
Start Date
2022-09-01
Completion Date
2027-10-01
Last Updated
2025-11-17
Healthy Volunteers
No
Conditions
Interventions
Sodium Hyaluronate
Sodium hyaluronate of molecular weight 35kDa will be given in capsule form to study participants
Placebo
A placebo will be given in capsule form to study participants
Locations (1)
Cleveland Clinic
Cleveland, Ohio, United States