Clinical Research Directory

Inclusion Criteria: 1. Ambulatory adults age ≥65 years with TTR-cardiac amyloidosis (confirmed by PYP scan or biopsy) 2. Taking beta-blocker Exclusion Criteria: 1. Other compelling indication(s) for beta-blockers: 1. Angina 2. Acute coronary syndrome, myocardial infarction or coronary artery bypass surgery in prior 3 years 3. Atrial arrhythmia with hospitalization for rapid ventricular response, prior 1 year 4. Heart rate \>100 bpm within the prior 3 months 5. Atrial arrhythmia with ventricular rate \>90 beats per minute within the prior 3 months 6. Systolic blood pressure readings \>160 mmHg within the prior 1 month, unless classified as white coat hypertension/effect (e.g., migraine prevention, anxiety symptom management, hyperthyroidism, essential tumor reduction) 2. Clinical instability (N-of-1 trials are appropriate for stable conditions only) 1. Decompensated heart failure 2. Hospitalized in the past 30 days 3. Medication changes or procedures in the prior 14 days that could confound observations/data at Principal Investigator discretion 4. Anticipated medication changes or procedures in subsequent 3 months that could confound observations/data at PI discretion 5. Clinical instability from other medical issues 3. Estimated life expectancy \<6 months 4. Moderate-severe dementia or psychiatric disorder precluding informed consent 5. Language barrier that will preclude informed consent and ability to comprehend study procedures 6. Non-compliance or inability to complete study procedures 7. Enrollment in a clinical trial not approved for co-enrollment 8. Any condition that, in Principal Investigator or treating physician's opinion, makes the patient unsuitable for study participation