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Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease
Sponsor: James Liao
Summary
The purpose of this study is to assess how alternating-frequency Deep Brain Stimulation (DBS) works to improve postural instability and gait, while also treating other motor symptoms of Parkinson Disease (PD).
Official title: ENGAGE-PD: Enhancing Gait Using Alternating-Frequency DBS in Parkinson Disease
Key Details
Gender
All
Age Range
21 Years - Any
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2021-10-04
Completion Date
2026-05
Last Updated
2026-01-13
Healthy Volunteers
No
Conditions
Interventions
High-Frequency-Only Stimulation
Control condition, constant high-frequency DBS stimulation (130Hz)
Low-Frequency-Only Stimulation
Experimental condition, constant low-frequency DBS stimulation (60 Hz)
Alternating, 50 sec High-Frequency, 10 sec Low-Frequency Stimulation
Experimental condition where stimulation frequency is changed from high (130Hz) to low (60Hz) frequency. The time interval for each frequency is 50 seconds for high, and 10 seconds for low, respectively.
Alternating, 50 sec High-Frequency, 50 sec Low-Frequency Stimulation
Experimental condition where stimulation frequency is changed from high (130Hz) to low (60Hz) frequency. The time interval for each frequency is 50 seconds for high, and 50 seconds for low, respectively.
Alternating, 10 sec High-Frequency, 50 sec Low-Frequency Stimulation
Experimental condition where stimulation frequency is changed from high (130Hz) to low (60Hz) frequency. The time interval for each frequency is 10 seconds for high, and 50 seconds for low, respectively.
Alternating, 10 sec High-Frequency, 10 sec Low-Frequency Stimulation
Experimental condition where stimulation frequency is changed from high (130Hz) to low (60Hz) frequency. The time interval for each frequency is 10 seconds for high, and 10 seconds for low, respectively.
OFF Dopaminergic Medication
All six device interventions will be performed in medication OFF state
ON Dopaminergic Medication
All six device interventions will be performed in medication ON state
Locations (1)
Cleveland Clinic Foundation
Cleveland, Ohio, United States