Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
ACTIVE NOT RECRUITING
NCT05023980
PHASE3

A Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab (BR) in Untreated Patients With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Sponsor: Loxo Oncology, Inc.

View on ClinicalTrials.gov

Summary

The purpose of this study is to compare the efficacy and safety of pirtobrutinib (LOXO-305; Arm A) compared to BR (Arm B) in patients with CLL/SLL who have not been treated. Participation could last up to five years.

Official title: A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab in Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

309

Start Date

2021-09-23

Completion Date

2027-10

Last Updated

2026-01-22

Healthy Volunteers

No

Interventions

DRUG

Pirtobrutinib

Oral

DRUG

Bendamustine

IV

DRUG

Rituximab

IV

Locations (108)

California Research Institute

Los Angeles, California, United States

Innovative Clinical Research Institute

Whittier, California, United States

Oncology-Hematology Associates of West Broward

Coral Springs, Florida, United States

New Jersey Center for Cancer Research

Brick, New Jersey, United States

Clinical Research Alliance, Inc.

Westbury, New York, United States

Liverpool Hospital

Liverpool, New South Wales, Australia

Westmead Hospital

Wentworthville, New South Wales, Australia

Peninsula Private Hospital

Frankston, Victoria, Australia

Uniklinikum Salzburg

Salzburg, Austria

Klinik Ottakring

Vienna, Austria

Hospital de Clinicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Irmandade da Santa Casa de Misericórdia de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Centro Gaucho Integrado - Mae de Deus Center

Porto Alegre, Rio Grande do Sul, Brazil

Hemocentro Unicamp

Campinas, São Paulo, Brazil

Fundação Doutor Amaral Carvalho

Jaú, São Paulo, Brazil

UMHAT "Sveti Georgi" EAD

Plovdiv, Bulgaria

UMHAT 'Sv. Ivan Rilski', EAD

Sofia, Bulgaria

"SHATHD" EAD, Sofia

Sofia, Bulgaria

UMHAT - Prof. Dr. Stoyan Kirkovich" AD

Stara Zagora, Bulgaria

Anhui Provincial Cancer Hospital

Hefei, Anhui, China

Peking University First Hospital

Beijing, Beijing Municipality, China

Peking University Third Hospital

Beijing, Beijing Municipality, China

The First Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, Hubei, China

Xiangya Hospital Central South University

Changsha, Hunan, China

Hunan Cancer Hospital

Changsha, Hunan, China

The Affiliated Hospital of Inner Mongolia Medical University

Hohhot, Inner Mongolia, China

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China

Shengjing Hospital of China Medical University

Shenyany, Liaoning, China

Jiangsu Province Hospital

Nanjing, Nanjing, China

Shanghai Tongren Hospital

Changning District, Shanghai Municipality, China

West China Hospital of Sichuan University

Chengdu, Sichuan, China

Institute of hematology&blood disease hospital

Tianjin, Tianjin Municipality, China

Tianjin Medical University Cancer Institute and Hospital

Tianjin, Tianjin Municipality, China

The First People's Hospital of Hangzhou Linping District

Hangzhou, Zhejiang, China

Beijing Hospital

Beijing, China

Chongqing Cancer Hospital

Chongqing, China

Henan Cancer Hospital

Zhengzhou, China

Fakultni nemocnice Brno

Brno, Czechia

Fakultni nemocnice Hradec Kralove

Hradec Králové, Czechia

Hospitalier Le Mans

Le Mans, France

Debreceni Egyetem Orvos-es Egészsegtudomanyi Centrum

Debrecen, Hungary

SzSzB Megyei Korhazak es Egyetemi Oktatokorhaz

Nyíregyháza, Hungary

Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz

Székesfehérvár, Hungary

Irccs Crob

Rionero in Vulture, Potenza, Italy

Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII

Bergamo, Italy

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

Brescia, Italy

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

Meldola, Italy

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico

Milan, Italy

ASST Grande Ospedale Metropolitano Niguarda Comitato Etico Milano Area C

Milan, Italy

Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo)

Monza, Italy

Azienda Ospedale Maggiore Della Carita

Novara, Italy

Istituto di Ematologia-C.R.E.O. (Centro di Ricerche Emato-Oncologich)

Perugia, Italy

Ospedale Santa Maria delle Croci

Ravenna, Italy

Azienda Ospedaliera Santa Maria Terni

Terni, Italy

Azienda sanitaria integrata università di Trieste

Trieste, Italy

Nagoya City University Hospital

Nagoya, Aichi-ken, Japan

Chiba Cancer Center

Chiba, Chiba, Japan

Fukui Medical University Hospital

Yoshida-Gun, Fukui, Japan

Hokuyukai Sapporo Hokuyu Hospital

Sapporo, Hokkaido, Japan

Kochi Medical School Hospital

Nankoku, Kochi, Japan

Tohoku University Hospital

Sendai, Miyagi, Japan

NHO Sendai Medical Center

Sendai, Miyagi, Japan

Dokkyo Medical University - Koshigaya Hospital

Koshigaya, Saitama, Japan

University of Yamanashi Hospital

Chūō, Yamanshi, Japan

Aomori Prefectural Centeral Hospital

Aomori, Japan

JCHO Kyushu Hospital

Fukoka-ken, Japan

North Shore Hospital, Haematology Research

Takapuna, Auckland, New Zealand

Tauranga Hospital

Tauranga, Bay of Plenty, New Zealand

Christchurch Hospital

Christchurch, New Zealand

Middlemore Clinical Trials

Papatoetoe, New Zealand

Wojewodzki Szpital Specjalistyczny

Iwaszkiewicza 5, Legnica, Poland

Klinika Hematoonkologii i Transplantacji Szpiku SPSK1 Lublin

Lublin, Lubelskie V, Poland

Uniwersyteckie Centrum Kliniczne

Gdansk, Pomeranian Voivodeship, Poland

Centrum Medyczne Pratia Poznan

Skorzewo, Poznan, Poland

KO-MED Centra Kliniczne

Biała Podlaska, Poland

Szpital Uniwersytecki nr 1 im. Antoniego Jurasza

Bydgoszcz, Poland

Pratia Onkologia Katowice

Katowice, Poland

Pratia MCM Krakow

Krakow, Poland

Centrum Onkologii Ziemi Lubelskiej

Lublin, Poland

Nasz Lekarz Osrodek Badan Klinicznych

Torun, Poland

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Cuire - Państwowy Instytut Badawczy

Warsaw, Poland

Uniwersytecki Szpital Kliniczny Klinika

Wroclaw, Poland

Centro Clínico Académico - Braga (2CA-Braga) (Hospital de Braga)

Braga, Portugal

Centro Hospitalar de Lisboa Norte, E.P.E. - Hospital de Santa Maria

Lisbon, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil, EPE

Porto, Portugal

Spitalul Clinic Municipal Filantropia Craiova

Craiova, Dolj, Romania

Institutul Clinic Fundeni - Centrul de Hematologie si Transplant Medular

Bucharest, Romania

Institutul Oncologic "Prof. Dr. Ion Chiricuta" Cluj-Napoca

Cluj-Napoca, Romania

Institutului Regional de Oncologie IASI

Iași, Romania

Academician I.P. Pavlov First St-Petersburg State Medical University

Saint Petersburg, Russia

Gachon University Gil Medical Center

Namdong-gu, Incheon-gwangyeoksi [Incheon], South Korea

The Catholic University of Korea-Seoul St. Mary's Hospital

Seocho-Gu, Seoul, South Korea

Seoul National University Hospital

Seoul, Seoul, Korea, South Korea

Severance Hospital, Yonsei University Health System

Seoul, Seoul-teukbyeolsi [Seoul], South Korea

Samsung Medical Center

Seoul, Seoul-teukbyeolsi [Seoul], South Korea

Inje Univ Busan Paik Hospital

Busan, South Korea

Hospital Universitario HM Sanchinarro

Madrid, Madrid, Comunidad de, Spain

Hospital Universitario Central de Asturias

Oviedo, Principality of Asturias, Spain

Hospital de la Santa Creu i Sant Pau

Barcelona, Spain

Hospital Universitario Fundación Jiménez Díaz

Madrid, Spain

Hospital Universitario Virgen del Rocío

Seville, Spain

Hospital Universitario Virgen de Valme

Seville, Spain

Chang Bing Show Chwan Memorial Hospital

Changhua, Taiwan

China Medical University Hospital

Taichung, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Chang Gung Memorial Hospital - Linkou

Taoyuan, Taiwan

Birmingham Heartlands Hospital

Birmingham, England, United Kingdom