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HA35 Acute Alcohol Study
Sponsor: The Cleveland Clinic
Summary
Eligible subjects will be asked to take a placebo/treatment capsule for a total of 3 days and then participate in a study visit on the fourth day. This study visit will include a medical exam, clinical labs, questionnaires, body composition measurements, and urine and stool collections. Additionally, participants will consume a sugar cocktail to measure their gut permeability, participate in an acute ethanol challenge, and undergo two muscle biopsies. The study will take approximately 3-4 hours and a designated driver will need to drive the participant home. On the fifth day, you will be asked to return to drop of the 24-hour urine collection.
Official title: Mechanisms by Which HA35 Regulates Muscle Protein Homeostasis in Healthy Controls
Key Details
Gender
All
Age Range
21 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2022-02-01
Completion Date
2027-10-01
Last Updated
2025-11-17
Healthy Volunteers
Yes
Conditions
Interventions
Sodium Hyaluronate
Sodium Hyaluronate of molecular weight 35 kDa will be given in capsule form to the study participants.
Placebo
A placebo will be given in capsule form to study participants.
Locations (1)
Cleveland Clinic
Cleveland, Ohio, United States