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13C-Glucose Tracing of Tumour and T Cells in the Ascites of Ovarian Cancer Patients.
Sponsor: British Columbia Cancer Agency
Summary
The objective of the study is to investigate the metabolism of cells in the ascites tumour microenvironment of ovarian cancer patients. This observational study involves intravenous infusion of \[U-13C\]glucose into patients during standard paracentesis.
Official title: Metabolic Tracing of Tumour and T Cells in the Ascites of Ovarian Cancer Patients
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
10
Start Date
2021-10-20
Completion Date
2024-08
Last Updated
2024-08-09
Healthy Volunteers
No
Conditions
Interventions
[U-13C]Glucose
Patients are intravenously infused with 28g of \[U-13C\]glucose over a 5 hour period. Briefly, \[U-13C\]glucose will be provided by intravenous line containing 8g of \[U-13C\]glucose in 60 mL over 10 min. After 10 minutes, 4g of \[U-13C\]glucose will be administered over an hour. This process will continue until the patient's ascites is drained, or after 5 hours. We will monitor blood glucose levels during infusions using a continuous glucose monitor.
Locations (1)
Jennifer Rauw
Victoria, British Columbia, Canada