Clinical Research Directory

Inclusion Criteria: * Age ≥ 18 years * Anaphylactic reaction to a COVID-19 vaccine administered by Pfizer-BioNtech or Janssen or Vaxzevria or Moderna, at least 3 weeks old at the time of the allergology consultation. An anaphylactic reaction is defined as the occurrence of any of the following systemic manifestations within a few hours of administration of a COVID-19 vaccine: * skin rash with urticaria and/or angiodema, * and/or associated with respiratory signs (dyspnea, bronchospasm, desaturation), and/or digestive disorders (intense abdominal pain, diarrhea, vomiting, nausea), and/or neurological disorders (loss of consciousness, feeling of malaise), and/or hypotension, tachycardia. * Affiliation to a Social Security system * Signature of the informed consent * Stop taking antihistamines at least 3 days before skin allergy tests are performed Exclusion Criteria: * Other non-anaphylactic systemic reactions after administration of COVID-19 mRNA vaccine (serum sickness, vasculitis, Guillain-Barré syndrome) * Pregnancy and lactation * Disorders of hemostasis or severe bleeding considered a contraindication to intramuscular injection