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RECRUITING
NCT05028738
NA

Patient-oriented Randomized Pragmatic Feasibility Trial with RTMS in Depression and Anxiety

Sponsor: University of British Columbia

View on ClinicalTrials.gov

Summary

This trial compares intermittent theta-burst stimulation (iTBS) to low frequency repetitive transcranial magnetic stimulation (LFR) in regards to depression and anxiety outcomes in 100 patients with treatment resistant depression (TRD).

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

100

Start Date

2021-10-11

Completion Date

2025-08

Last Updated

2024-12-20

Healthy Volunteers

No

Interventions

DEVICE

Repetitive Transcranial Magnetic Stimulation

rTMS will employ the MagPro X100 stimulator equipped with the cool-B70 coil (MagVenture, Farum, Denmark). The dose will be a 120% resting motor threshold (rMT) in accordance to our latest trial using iTBS. Localization of the right and left DLPFC will follow the well-established Beam F3 procedure. Subjects will then undergo 30 sessions of rTMS, once daily on weekdays for 6 weeks. FDA-approved iTBS protocol will consist of bursts of 3 pulses at 50 Hz, bursts repeated at 5 Hz for 600 pulses total, 2 s on, 8 s off, for 3 min 9 sec, at 120% rMT. LFR will consist of 1 Hz stimulation consisting of a single train of 10min duration for 600 pulses total at 120% rMT.

Locations (1)

Non-Invasive Neurostimulation Therapies (NINET) Laboratory, UBC Department of Psychiatry

Vancouver, British Columbia, Canada