Clinical Research Directory

Inclusion Criteria: * Age ranging from 18 to 80, both genders * Unilateral internal carotid artery (ICA) or M1 segment of middle cerebral artery (MCA) stenosis (rate of stenosis ranging from 50-99%) * Acute ischemic cerebrovascular events (TIA or ischemic stroke) within cerebral stenotic artery supplying area * Onset of disease \<30 d before enrollment * Modified Ranking Scale (mRS) ≤1 before stroke onset * National Institutes of Health Stroke Scale (NIHSS) ≤20 * Sufficient bilateral temporal bone windows for insonation of the middle cerebral artery * Be conscious, and able to cooperate with CA assessment * Willing to participate and sign the informed consent Exclusion Criteria: * Vertebral artery (VA), basilar artery (BA), anterior cerebral artery (ACA), or posterior cerebral artery (PCA) stenosis; Bilateral internal carotid artery (ICA) or M1 segment of middle cerebral artery (MCA) stenosis(rate of stenosis ranging from 50-99%) * Patients who have received or plan to undergo intravascular interventional treatment/endarterectomy * Other intracranial diseases, including cerebral hemorrhage (primary or secondary), intracranial neoplasm, aneurysm, arteriovenous malformation, etc. * Evidence for embolic stroke, such as atrial fibrillation, prosthetic valve surgery, and suspected endocarditis, etc. * Arrhythmia, anemia and hyperthyroidism which may influence the stability of cerebral blood flow diagnosed by two physicians by electrocardiogram and laboratory tests. * Dementia, severe anxiety, depression, and other mental diseases * Malignant neoplasm and expected lifetime \<2 years * Enrolled in other clinical trails within 6 months