Clinical Research Directory

Inclusion Criteria: * At least one episode of atrial fibrillation\* that is documented during the prior year by any kind of ECG recording. * Diabetes mellitus type II was diagnosed. (HBA1c \>6.5%) and are using oral hypoglycemic agents only * At least 20 years old and not older than 80 years old. * Normal ECG parameters when measured in sinus rhythm (QRS width ≤120 ms, QTc interval \<440 ms, and PQ interval ≤210 ms in a 12 lead ECG) * Able and willing to give informed consent. Exclusion Criteria: * Any disease that limits life expectancy under 1 year * Subject for another clinical trial within the past 2 months * Under 20 years old or over 80 years old * Pregnant women * Lactating women * Drug abuser * Type 2 DM treated by recombinant insulin * Diagnosis of Type 1 DM, MODY, or secondary DM * HbA1c ≥12% or HbA1c \<6.5% at diagnosis * Previous treatment with any SGLT2 inhibitor * Renal dysfunction (eGFR-CKD-EPI \<30ml/min/1.73m\^2) * Chronic cystitis and/or recurrent genitourinary tract infections (3 or more in the last year) * Unexplained hematuria at baseline study * Systolic BP \>180mmHg or diastolic BP \>100mmHg at baseline study * Systolic BP \<95mmHg at baseline study * Previous treatment with AF ablation * Acute cardiovascular event \[e.g., stroke, acute coronary syndrome (ACS), revascularization, decompensated HF, sustained ventricular tachycardia, return of spontaneous circulation (ROSC)\] \<8 weeks prior to baseline study * Severe valvular disease or have prosthetic valve * Treatment with chronic oral steroid (\>30 consecutive days) at a dose equivalent to oral prednisolone ≥10mg/d, within the past 1 month * History of any malignancy within 5 years * Clinically profound hepatic dysfunction * Clinically uncontrolled thyroid dysfunction * Patients incapable of completing the trial due to any severe medical condition by clinical decision * Patients with poor compliance (defined as 80 - 120%), except for reasonable situations judged by physician