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Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation
Sponsor: Assiut University
Summary
the aim of the study is to approve the hypothesis that dexmedetomidine can protect against glycocalyx degradation induced by hepatic ischemia-reperfusion injury and hence can reduce the subsequent complications as early allograft dysfunction, other organ dysfunction and hemodynamic instability
Official title: Dexmedetomidine Infusion to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in the Sitting of Adult Living Donor Liver Transplantation
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2022-03-15
Completion Date
2026-02-15
Last Updated
2025-10-02
Healthy Volunteers
No
Conditions
Interventions
Dexmedetomidine
dexmedetomidine infusion rule in prevention of IRI
Normal Saline
normal saline infusion as a placebo
Locations (1)
Assiut University
Asyut, Egypt