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Changing the Natural History of Type 2 Diabetes ("CHANGE" Study)
Sponsor: Foundation for Atlanta Veterans Education and Research, Inc.
Summary
Diabetes is a disorder of high blood glucose, that tends to get worse; over time, patients need more and more drugs. This pattern is caused by overwork of the body's insulin-producing β-cells, because patients' glucose levels are typically above normal; if the investigators kept glucose levels normal - reducing β-cell work - the investigators might be able to keep the disease from getting worse. This trial is aimed to show that adjusting the drugs to keep glucose levels normal, can help to preserve β-cell function compared to usual diabetes care, possibly reduce the tendency to develop the eye and kidney complications of diabetes, and might also be more cost-effective than usual care.
Key Details
Gender
All
Age Range
40 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
127
Start Date
2021-09-01
Completion Date
2027-03-31
Last Updated
2025-05-06
Healthy Volunteers
No
Conditions
Interventions
Intensification of diabetes medication based largely on HbA1c levels
Use of diabetes Rx in controls will be guided largely by HbA1c levels.
Intensification of diabetes medication based on glucose levels
Use of diabetes Rx in the intensive Rx groups will be guided by participants' self-monitored blood glucose levels (SMBG), with management aimed to keep glucose levels within the normal range.
Locations (1)
Atlanta VA Medical Center
Decatur, Georgia, United States