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Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)
Sponsor: University of Oxford
Summary
The trial will develop and validate a platform for quantitative assessment of antiviral effects in low-risk patients with high viral burdens and uncomplicated COVID-19 to determine in-vivo antiviral activity. In this randomized open label, controlled, group sequential adaptive platform trial, we will assess the performance of three distinct types of intervention relative to control (no treatment): A: Small molecule drugs; B: Monoclonal antibodies; C: Dose finding for the constituent parts of nirmatrelvir/ritonavir PLATCOV study is supported by the Wellcome Trust Grant ref: 223195/Z/21/Z through the COVID-19 Therapeutics Accelerator.
Official title: Finding Treatments for COVID-19: A Phase 2 Multi-centre Adaptive Platform Trial to Assess Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
3800
Start Date
2021-09-30
Completion Date
2027-01
Last Updated
2026-02-19
Healthy Volunteers
No
Conditions
Interventions
Nirmatrelvir/ritonavir (e.g. PAXLOVID™)
Nirmatrelvir 300mg BD for 5/7 Ritonavir 100mg BD for 5/7
Nitazoxanide
Nitazoxanide 1.5g BD 7/7
Molnupiravir and nirmatrelvir/ritonavir (e.g. PAXLOVID™)
Molnupiravir 800mg BD for 5/7, Nirmatrelvir 300mg BD for 5/7, Ritonavir 100mg BD for 5/7
Hydroxychloroquine
Hydroxychloroquine 400mg D0 BD and 400MG OD for a further 6/7
No treatment
No treatment (except antipyretics- paracetamol)
Monoclonal antibodies
Monoclonal antibodies: 300mg tixagevimab/ 300 mg cilgavimab given once on D0
Fluoxetine
Fluoxetine 40mg OD for 7/7
Molnupiravir
Molnupiravir 800mg BD for 5/7
Sotrovimab
Sotrovimab 500mg given once on D0
Ensitrelvir
Ensitrelvir 375mg OD D0 and 125mg OD for a further 4/7
Monoclonal antibodies
Monoclonal antibodies: 600mg casirivimab/ 600mg imdevimab given once on D0
Favipiravir
Favipiravir 1800mg BD D0 and 800mg BD for a further 6/7
Ivermectin
Ivermectin 600micrograms/kg/day for 7/7.
Remdesivir
Remdesivir 200mg D0 and 100mg for a further 4/7.
Atilotrelvir/ritonavir
Atilotrelvir 150mg BD for 5/7 Ritonavir 100mg BD for 5/7
Metformin
Metformin 500mg TDS 5/7
Nirmatrelvir/ritonavir
Nirmatrelvir 300mg BD for 5/7 Ritonavir 50mg BD for 5/7
Nirmatrelvir/ritonavir
Nirmatrelvir 150mg BD for 5/7 Ritonavir 50mg BD for 5/7
Nirmatrelvir
Nirmatrelvir 300mg BD for 5/7
Locations (7)
Universidade Federal de Minas Gerais
Minas Gerais, Brazil
Laos-Oxford-Mahosot Wellcome Trust Research Unit
Vientiane, Laos
Sukraraj Tropical & Infectious Disease Hospital
Kathmandu, Nepal
The Aga Khan University Hospital
Karachi, Pakistan
Vajira hospital
Bangkok, Thailand
Faculty of Tropical Medicine, Mahidol University
Bangkok, Thailand
Bangplee Hospital
Mueang Samut Prakan, Thailand