Clinical Research Directory

Inclusion Criteria: * Patients aged 7 to 17 who have irritability symptoms will be recruited. They will be screened for the irritability symptoms with ARI scale. Exclusion Criteria: * Patients who are not willing to participate in the study after detailed explanation. * Patients who could not follow the investigator's instructions. * Patients who have problems to express questions or emotional problems exactly. * Patients who have severe neurological or mental illness like epileptic disorder, history of stroke, schizophrenia, bipolar disorder, mental retardation or uncontrolled suicide risk. * Patients who have severe medical illness or surgical conditions like uncontrolled abnormal thyroid function, history of heart attack, uncontrolled hypertension. * Patients who are allergic to methylphenidate or dextromethorphan. * Patients with autoimmune disorders * Patients with asthma or severe infection disorder currently or in the previous two months to avoid the influence of the level of cytokines.