Clinical Research Directory

Inclusion Criteria: * Patients with a sepsis diagnosis, according to the diagnostic criteria of the International Sepsis-3 Consensus Conference, and without response to the treatment of septic shock who meet the following conditions: * Sepsis of abdominal origin with controlled infectious focus. * Noradrenaline dose\> 0.5 µg / kg / min to maintain adequate organ perfusion after optimization of fluid therapy. * Dysfunction of two or more organs with SOFA ≥ 9 (5). * Blood lactate ≥ 2 mmol / L. * Procalcitonin (PCT)\> 10 ng / mL. * CRP\> 100 mg / L. * IL-6\> 2000 pg / ml. Exclusion Criteria: * Age under 18 years or over 80 years. * Pregnancy or breastfeeding. * Terminally ill patients or with a life expectancy of less than 48 hours. * Thrombocytopenia \<60,000 / mm3. * Pancytopenia. * Severe coagulopathy with high risk of bleeding. * Inclusion in another research protocol. * In case of re-entry during the study period, only the first admission will be included. * Use of another haemoperfusion device.