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Preventive Therapy of Postoperative Intra-abdominal Infection Based on Serum Lactate Changes
Sponsor: Peking Union Medical College Hospital
Summary
Intra-abdominal infection is one of the most serious complications after pancreatic resection. The preventive use of antibiotics intraoperatively could reduce the incidence rate of postoperative intra-abdominal infection. According to the previous retrospective study, changes of serum lactate level on postoperative day1 could predict the incidence rate of postoperative intra-abdominal infection. This prospective RCT is to further validate and promote the findings and conclusion.
Official title: A Prospective, Randomized Clinical Trial to Treat Intra-abdominal Infection Preventively After Pancreatic Surgery Based on Serum Lactate Changes
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
297
Start Date
2021-07-01
Completion Date
2026-07-01
Last Updated
2021-09-27
Healthy Volunteers
No
Interventions
Preventive use of advanced antibiotics
Treat patients in this group with advanced preventive usage of antibiocs: Sulperazon 3g q8h, in postoperative days 1-5.
Routine
Treat patients in this group with routine preventive usage of antibiocs: Cefmetazole 1g q12h, in postoperative days 1-3.
Locations (1)
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China