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Image Supported Lead Placement in CRT
Sponsor: UMC Utrecht
Summary
Cardiac resynchronization therapy (CRT) is an established pacemaker therapy for patients with symptomatic chronic heart failure, but is hampered by a non-response rate of 30-40%. Optimising left ventricular (LV) lead placement is the cornerstone of improving treatment. The optimal location for the lead is remote from scar but within segments demonstrating late electromechanical activation. The present study aims to investigate the efficacy and clinical effect of the use of real-time guided lead placement using cardiac MRI and fluoroscopy in a blinded, multicenter, randomized controlled trial.
Official title: Advanced Image Supported Lead Placement in Cardiac Resynchronization Therapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
130
Start Date
2021-02-08
Completion Date
2025-10
Last Updated
2025-04-01
Healthy Volunteers
No
Conditions
Interventions
CARTBox
CARTBox performs analysis of cardiac MRI scans. The result is a treatment file that displays optimal targets for left ventricular lead implantation in CRT. This file will be used as an overlay with live fluoroscopy during the implantation procedure in the intervention group.
Locations (7)
Erasmus MC
Rotterdam, South Holland, Netherlands
Amsterdam UMC
Amsterdam, Netherlands
UMC Groningen
Groningen, Netherlands
Maastricht UMC+
Maastricht, Netherlands
St. Antonius Nieuwegein
Nieuwegein, Netherlands
UMC Utrecht
Utrecht, Netherlands
Isala Zwolle
Zwolle, Netherlands