Clinical Research Directory

Inclusion Criteria: * Women presenting to MDACC for the evaluation of PND as the main or accompanying symptom * Age 25-85 years * Willing to participate in the study and undergo an IV placement, able to undergo iodinated contrast injection, and able to provide informed consent Exclusion Criteria: * Reported history of an allergic reaction to iodinated contrast * History of anaphylactic reaction to any substance in the absence of a prior history of uneventful administration of iodine-based IV contrast. * Renal insufficiency * Pregnancy or lactation within 6 months * Breast surgery affecting the symptomatic breast within prior 6 months, if it was located within 5 cm from the nipple * Breast biopsy of the symptomatic breast within the last 2 months, if it was located within 5 cm from the nipple * Breast MRI performed within 24 months before the patient presented with qualifying symptoms (MRI performed contemporarily with CEM for the evaluation of new symptoms is not an exclusion criterion). * Known breast cancer or active inflammatory process (such as abscess or mastitis) in the breast of concern