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Realistic Computational Electrophysiology Simulations for the Targetted Treatment of Atrial Fibrillation
Sponsor: University of Edinburgh
Summary
The aim of this research is to classify patients by the dominant mechanism of continuous atrial electrical activation during atrial fibrillation. This approach seeks to improve on existing classifications which are based solely on the duration of the arrhythmia (\<7 days, \>7 days and \>1 year). This is a cohort study. Patients undergoing clinically indicated electrophysiology study or AF ablation will have invasive assessment of cardiac electrophysiological profile at the time of their planned procedure, undergo 2-week ambulatory monitoring before and after the procedure, complete symptom questionnaires before and after their procedure and undergo atrial cardiac magnetic resonance imaging before their procedure.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
91
Start Date
2022-07-01
Completion Date
2026-03-31
Last Updated
2026-04-03
Healthy Volunteers
Not specified
Conditions
Interventions
Atrial cardiac magnetic resonance imaging
To include assessment of atrial size, shape, function, fibrosis and fat
Atrial electro-anatomic mapping
To include assessment of atrial voltage and local activation time
Atrial fibrillation symptom questionnaire
To include assessment of atrial fibrillation symptoms and quality of life
Patch-based 2 week ambulatory monitor
To assess atrial fibrillation burden post-ablation
Locations (2)
NHS Lothian
Edinburgh, United Kingdom
Guy's and St Thomas' NHS Foundation Trust
London, United Kingdom