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ACTIVE NOT RECRUITING
NCT05057507

Realistic Computational Electrophysiology Simulations for the Targetted Treatment of Atrial Fibrillation

Sponsor: University of Edinburgh

View on ClinicalTrials.gov

Summary

The aim of this research is to classify patients by the dominant mechanism of continuous atrial electrical activation during atrial fibrillation. This approach seeks to improve on existing classifications which are based solely on the duration of the arrhythmia (\<7 days, \>7 days and \>1 year). This is a cohort study. Patients undergoing clinically indicated electrophysiology study or AF ablation will have invasive assessment of cardiac electrophysiological profile at the time of their planned procedure, undergo 2-week ambulatory monitoring before and after the procedure, complete symptom questionnaires before and after their procedure and undergo atrial cardiac magnetic resonance imaging before their procedure.

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

OBSERVATIONAL

Enrollment

91

Start Date

2022-07-01

Completion Date

2026-03-31

Last Updated

2026-04-03

Healthy Volunteers

Not specified

Interventions

DIAGNOSTIC_TEST

Atrial cardiac magnetic resonance imaging

To include assessment of atrial size, shape, function, fibrosis and fat

DIAGNOSTIC_TEST

Atrial electro-anatomic mapping

To include assessment of atrial voltage and local activation time

OTHER

Atrial fibrillation symptom questionnaire

To include assessment of atrial fibrillation symptoms and quality of life

DIAGNOSTIC_TEST

Patch-based 2 week ambulatory monitor

To assess atrial fibrillation burden post-ablation

Locations (2)

NHS Lothian

Edinburgh, United Kingdom

Guy's and St Thomas' NHS Foundation Trust

London, United Kingdom