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Endometriosis and Microvascular Dysfunction; Simvastatin and Duavee
Sponsor: Penn State University
Summary
Purpose: To determine the effects of SERM and simvastatin interventions on endothelial dysfunction in women with endometriosis. Hypothesis: Treatment with the SERM (bazedoxifene + conjugated estrogen) or with simvastatin will decrease systemic inflammation and improve specific measures of cardiovascular function including endothelium-dependent vasodilation.
Official title: Mechanisms and Interventions Addressing Accelerated Cardiovascular Disease Risk in Women With Endometriosis
Key Details
Gender
FEMALE
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
28
Start Date
2023-12-01
Completion Date
2026-12-31
Last Updated
2024-11-05
Healthy Volunteers
No
Conditions
Interventions
simvastatin 10mg
Simvastation acts as a systemic LOX inhibitor.
Bazedoxifene 20/Estrogens,Con 0.45Mg Tb
Duavee is a selective estrogen receptor modulator.
Locations (1)
The John B. Pierce Laboratory
New Haven, Connecticut, United States