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RECRUITING
NCT05059626
PHASE4

Endometriosis and Microvascular Dysfunction; Simvastatin and Duavee

Sponsor: Penn State University

View on ClinicalTrials.gov

Summary

Purpose: To determine the effects of SERM and simvastatin interventions on endothelial dysfunction in women with endometriosis. Hypothesis: Treatment with the SERM (bazedoxifene + conjugated estrogen) or with simvastatin will decrease systemic inflammation and improve specific measures of cardiovascular function including endothelium-dependent vasodilation.

Official title: Mechanisms and Interventions Addressing Accelerated Cardiovascular Disease Risk in Women With Endometriosis

Key Details

Gender

FEMALE

Age Range

18 Years - 45 Years

Study Type

INTERVENTIONAL

Enrollment

28

Start Date

2023-12-01

Completion Date

2026-12-31

Last Updated

2024-11-05

Healthy Volunteers

No

Conditions

Interventions

DRUG

simvastatin 10mg

Simvastation acts as a systemic LOX inhibitor.

DRUG

Bazedoxifene 20/Estrogens,Con 0.45Mg Tb

Duavee is a selective estrogen receptor modulator.

Locations (1)

The John B. Pierce Laboratory

New Haven, Connecticut, United States