Clinical Research Directory

Inclusion Criteria: * polymerase chain reaction (PCR) confirmed coronavirus infection (COVID-19) in hospitalized patients with severe risk factors in age from 18 years to 59 years, of both sexes, irrespective of national or ethnic origin * the duration of the COVID-19 disease is no more than 10 days * informed concent to participate in clinical trials * informed concent to to use reliable contraceptive methods while participating in a clinical trial Exclusion Criteria: * age less than 18 years old and over 59 years old * pregnancy or breastfeeding * hypersensitivity, allergy, intolerance to iodine, iodine-containing medicines * hypersensitivity to Remdesivir or its components * impaired consciousness, causing the impossibility of oral administration * conditions or circumstances that, in the opinion of the investigator, may affect the patient's safety or the quality of the results obtained * participation in another clinical trial, including in the period up to 2 months before this study * signs of multiple organ failure * alanine aminotransferase (ALT), aspartate aminotransferase (AST) is 5 or more times higher than normal * thrombocytopenia below 100 \* 10\^9/ l * decrease in glomerular filtration rate (GFR) less than 30 ml / min by 1.73 m2 * chronic heart failure with reduced ejection fraction * liver failure * coagulopathy * mechanical ventilation for 48 hours or more * extracorporeal membrane oxygenation (ECMO) * disseminated intravascular coagulation