Clinical Research Directory
Browse clinical research sites, groups, and studies.
ICCRT vs. CRT for Locally Advanced Nasopharyngeal Carcinoma
Sponsor: First Affiliated Hospital, Sun Yat-Sen University
Summary
This trial is a multi-center phase III clinical trial. The purpose of this trial is to explore whether concurrent chemoradiotherapy is not inferior to induction chemotherapy combined with concurrent chemoradiotherapy in patients with locally advanced nasopharyngeal carcinoma.
Official title: Induction Chemotherapy+Chemoradiotherapy vs. Chemoradiotherapy for Locally Advanced Nasopharyngeal Carcinoma
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
447
Start Date
2021-09-22
Completion Date
2027-08-31
Last Updated
2021-09-30
Healthy Volunteers
No
Interventions
Induction Chemotherapy
Induction regimens: TP (docetaxel 75 mg/m²; cisplatin 75 mg/m²) Q3w, TPF (docetaxel 60 mg/m²; cisplatin 60 mg/m²; 5-fluorouracil 600-750 mg/m² per day, continuous intravenous infusion d1-5) Q3w, or GP (gemcitabine: 1000 mg/m2 d1, d8; cisplatin 80 mg/m2) Q3w.
Concurrent Chemotherapy
Cisplatin 100 mg/m², Q3w.
Definitive Radiotherapy
For all patients, the prescribed dose is 66-70 Gy (once a day, 5 times a week).
Locations (1)
The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China