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ctDNA-Directed Post-Hepatectomy Chemotherapy for Patients With Resectable Colorectal Liver Metastases
Sponsor: M.D. Anderson Cancer Center
Summary
To determine if the detection of ctDNA after surgical resection of CLM can stratify patients into high and low-risk cohorts for early disease recurrence in order to inform post-operative adjuvant therapy.
Official title: Risk-Stratified Adjuvant Therapy: ctDNA-Directed Post-Hepatectomy Chemotherapy for Patients With Resectable Colorectal Liver Metastases
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2022-04-26
Completion Date
2027-02-28
Last Updated
2026-02-06
Healthy Volunteers
No
Conditions
Interventions
Leucovorin
Given by PO
5-FLUOROURACIL
Given by IV
Oxaliplatin
Given by PO
Irinotecan
Given by IV
Capecitabine
Given by IV
Bevacizumab
Given by IV
Locations (1)
M D Anderson Cancer Center
Houston, Texas, United States