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RECRUITING
NCT05062317
PHASE2

ctDNA-Directed Post-Hepatectomy Chemotherapy for Patients With Resectable Colorectal Liver Metastases

Sponsor: M.D. Anderson Cancer Center

View on ClinicalTrials.gov

Summary

To determine if the detection of ctDNA after surgical resection of CLM can stratify patients into high and low-risk cohorts for early disease recurrence in order to inform post-operative adjuvant therapy.

Official title: Risk-Stratified Adjuvant Therapy: ctDNA-Directed Post-Hepatectomy Chemotherapy for Patients With Resectable Colorectal Liver Metastases

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

120

Start Date

2022-04-26

Completion Date

2027-02-28

Last Updated

2026-02-06

Healthy Volunteers

No

Interventions

DRUG

Leucovorin

Given by PO

DRUG

5-FLUOROURACIL

Given by IV

DRUG

Oxaliplatin

Given by PO

DRUG

Irinotecan

Given by IV

DRUG

Capecitabine

Given by IV

DRUG

Bevacizumab

Given by IV

Locations (1)

M D Anderson Cancer Center

Houston, Texas, United States