Clinical Research Directory

Inclusion Criteria: * Inclusion criteria for interstitial cystitis/bladder pain syndrome (IC/BPS) patients will be: 1. Woman aged 18 to 60. 2. Have a clinical diagnosis of IC/BPS. 3. Pain, pressure, or discomfort in the bladder and/or pelvic area for the past 6 months or more, associated with lower urinary tract symptoms (such as frequency of urination), in the absence of other explanation of the symptoms (e.g., urinary tract infection). 4. Myofascial pain diagnosed with palpable contracted muscle fibers. 5. Pelvic muscle tenderness by assessment of pelvic floor muscles on digital pelvic examination. 6. Pelvic floor hypertonicity (PFH), measured using vaginal manometry (pressure \> 35 cm∙H2O). 7. Ability to provide informed consent. Exclusion Criteria: * Exclusion criteria consist of the following: 1. History of pelvic malignancy and sexually transmitted diseases. 2. Bleeding disorder such as coagulopathy 3. History of neurological disorders, such as spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis or myasthenia gravis. 4. Pregnancy, breast feeding or desiring for pregnancy in the coming year. 5. Subjects with history of pelvic surgery (e.g., pain from mid-urethral sling or pelvic mesh), 6. Pelvic malignancy (urinary tract, gynecologic, gastrointestinal) 7. Active fistula 8. Radiation cystitis 9. Cyclophosphamide cystitis 10. Pre-existing anorectal disorders 11. Infections near the injection sites 12. History of drug or alcohol abuse 13. Hypersensitivity to BoNT 14. Steroids or hormone usage will be carefully considered by the research team for inclusion. Participants with on-going BoNT therapies will not be screened until the complete drug washout is confirmed.