Clinical Research Directory

Inclusion Criteria: * Age 18 to 70 * Comfortable speaking and writing in English * Diagnosis of Bipolar Disorder II with current depression * Have a care partner/support person available throughout the study * Able to attend all in-person visits at UCSF as well as virtual visits * Having tried at least one previous medication trials for their bipolar disorder, each lasting at 6 weeks or more. Exclusion Criteria: * Current or previous diagnosis of Bipolar I Disorder * History of schizophrenia spectrum or psychotic disorder * Use of psychedelics within the past 6 months, including MDMA * Current diagnosis of cancer * Seizures that continue to the present * Fear of blood or needles * Regular use of medications that may have problematic interactions with psilocybin, including but not limited to antidepressants (Bupropion allowed), serotonin antagonists, some antipsychotics, dopamine agonists/antagonists, stimulants, opioids, and Lithium. * A health condition that makes this study unsafe or unfeasible, determined by study physicians