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Amygdala Memory Enhancement
Sponsor: Washington University School of Medicine
Summary
The objective is to understand how amygdala activation affects other medial temporal lobe structures to prioritize long-term memories. The project is relevant to disorders of memory and to disorders involving affect and memory, including traumatic brain injury and post-traumatic stress disorder.
Official title: Mechanisms of Amygdala-Mediated Memory Enhancement in Humans
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2021-11-01
Completion Date
2027-11-01
Last Updated
2025-07-17
Healthy Volunteers
No
Conditions
Interventions
Intracranial Stimulation
Electrodes localized to the BLA will be stimulated with either active-BLAES (0.5-3.5 mA, theta-modulated gamma burst) electrical stimulation for a 1-sec duration immediately following item image presentation or sham-BLAES (zero-amplitude). At later stages of the project, stimulation parameters and timing will be varied and triggered not at random, but by real-time closed-loop analysis of memory biomarkers in the medial temporal lobe.
Locations (1)
Washington University School of Medicine
St Louis, Missouri, United States