Clinical Research Directory

Microbiome Derived Metabolism and Pharmacokinetics

Sponsor: Rutgers, The State University of New Jersey

Summary

The investigators will perform single-dose pharmacokinetic (PK) studies in humans following administration of drugs with known microbiome derived metabolism (MDM) in parallel with preclinical studies. By directly comparing laboratory measurements to clinical results, the investigators will be able to confirm the relevance of MDM in vivo, create microbiome-dependent PK profiles of the MDM positive drugs, and establish methodology to capture the contribution of MDM to inter-individual variability in clinical drug PK profiles.

Official title: Incorporating Drug Metabolism by the Human Gut Microbiome Into Personalized Medicine

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