Clinical Research Directory

Inclusion Criteria: * Medical or surgical ICU patient * Ability to take oral or nasogastric tube within 48 hours of admission to ICU * Expected ICU length of stay and life expectancy at least 48 hours * Patient or POA capable of signing informed consent within 48 hours of ICU admission Exclusion Criteria: * Past medical history includes cirrhosis * Active alcohol withdrawal * Patients taking fluvoxamine prior to admission * Self-reported hypersensitivity to ramelteon * Incarcerated patients * Pregnant patients * Patients with acute neurological conditions including brain abscess, head bleed, meningitis * Patients who are transferred from an outside hospital where they have resided for greater than 4 days * Non-English speaking patients * Hearing-impaired patients requiring sign language for communication * Visually-impaired patients