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A Study of Guselkumab and Golimumab Combination Therapy in Participants With Active Psoriatic Arthritis
Sponsor: Janssen Research & Development, LLC
Summary
The purpose of this study is to evaluate the efficacy of guselkumab plus golimumab combination treatment in participants with active psoriatic arthritis (PsA) and inadequate response (IR) to prior anti-tumor necrosis factor-alpha (anti-TNF-alpha) therapies by assessing clinical response compared with guselkumab monotherapy.
Official title: A Phase 2a, Multicenter, Randomized, Double-blind Study Evaluating the Efficacy and Safety of Subcutaneously Administered Guselkumab and Golimumab Combination Therapy in Participants With Active Psoriatic Arthritis
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
91
Start Date
2021-10-25
Completion Date
2024-08-06
Last Updated
2026-07-23
Healthy Volunteers
No
Conditions
Interventions
Guselkumab
Guselkumab will be administered as a SC injection.
Golimumab
Golimumab will be administered as a SC injection.
Placebo
Placebo will be administered as a SC injection.
Locations (82)
Arizona Arthritis and Rheumatology Research PLLC
Phoenix, Arizona, United States
Arizona Arthritis and Rheumatology Research PLLC 1
Phoenix, Arizona, United States
Unity Health-White County Medical Center
Searcy, Arkansas, United States
HARAC Research Corp
Avon Park, Florida, United States
Bay Pines VA Healthcare System
Bay Pines, Florida, United States
Omega Research Consultants
DeBary, Florida, United States
South Coast Research Center
Miami, Florida, United States
Advanced Clinical Research of Orlando
Ocoee, Florida, United States
Millennium Research
Ormond Beach, Florida, United States
Atlanta Research Center for Rheumatology
Marietta, Georgia, United States
Great Lakes Center of Rheumatology
Lansing, Michigan, United States
Clinvest
Springfield, Missouri, United States
NYU Langone Ambulatory Care Brooklyn Heights
Brooklyn, New York, United States
NYU School of Medicine
New York, New York, United States
University of Rochester
Rochester, New York, United States
Jacobi Medical Center
The Bronx, New York, United States
STAT Research, Inc.
Vandalia, Ohio, United States
Trinity Universal Research Associates, LLC
Plano, Texas, United States
DM Clinical Research
Tomball, Texas, United States
Swedish Medical Center
Seattle, Washington, United States
Frederiksberg Hospital
Frederiksberg, Denmark
Rigshospitalet Glostrup
Glostrup Municipality, Denmark
Køge Sygehus Region Sjaelland
Køge, Denmark
Silkeborg Hospital
Silkeborg, Denmark
Vejle Sygehus
Vejle, Denmark
Centre Hospitalier Le Mans
Le Mans, France
Hopital Larrey CHU de Toulouse
Toulouse, France
CHU Trousseau - Service de Rhumatologie
Tours, France
Obudai Egeszsegugyi Centrum Kft
Budapest, Hungary
Bekes Varmegyei Kozponti Korhaz Pandy Kalman Tagkorhaz
Gyula, Hungary
Complex Rendelo Med Zrt
Székesfehérvár, Hungary
Vital Medical Center
Veszprém, Hungary
Azienda Ospedaliero-Universitaria di Cagliari
Cagliari, Italy
Centro Specialistico Ortopedico Traumatologico Gaetano Pini CTO
Milan, Italy
Ospedale San Raffaele
Milan, Italy
IRCCS Policlinico San Matteo, Università degli studi di Pavi
Pavia, Italy
Arcispedale Santa Maria Nuova - IRCCS
Reggio Emilia, Italy
A.O.U.Policlinico Tor Vergata
Roma, Italy
Policlinico Universitario Agostino Gemelli
Roma, Italy
Università Campus Biomedico di Roma
Rome, Italy
AO Ordine Mauriziano
Torino, Italy
Centrum Kliniczno Badawcze
Elblag, Poland
Centrum Terapii Wspolczesnej J M Jasnorzewska Spolka Komandytowo Akcyjna
Lodz, Poland
NZOZ Lecznica MAK MED S C
Nadarzyn, Poland
Centrum Medyczne
Poznan, Poland
Medycyna Kliniczna
Warsaw, Poland
Centrum Medyczne AMED Targowek
Warsaw, Poland
WroMedica I Bielicka A Strzalkowska s c
Wroclaw, Poland
Kemerovo State Medical University
Kemerovo, Russia
LLL Medical Center Revma-Med
Kemerovo, Russia
LLC Family Outpatient Clinic # 4
Korolyov, Russia
GBUZ of Moscow Region 'Moscow Region SRI n.a. Vladimirskyi'
Moscow, Russia
Orenburg State Medical Academy
Orenburg, Russia
Rostov Regional Clinical Dermatovenerological Dispensary
Rostov-on-Don, Russia
Ryazan Regional Clinical Dermatovenerological Dispensary
Ryazan, Russia
X7 Clinical Research Company Limited
Saint Petersburg, Russia
Smolensk regional hospital on Smolensk railway station
Smolensk, Russia
Republican Clinical Hospital - G.G. Kuvatov
Ufa, Russia
Clinical Hospital #3
Yaroslavl, Russia
Hosp Univ A Coruna
A Coruña, Spain
Hosp. Univ. Germans Trias I Pujol
Barcelona, Spain
Hosp. Univ. de Basurto
Bilbao, Spain
Hosp Reina Sofia
Córdoba, Spain
Hosp. Univ. 12 de Octubre
Madrid, Spain
Corporacio Sanitari Parc Tauli
Sabadell, Spain
Hosp. Clinico Univ. de Santiago
Santiago de Compostela, Spain
Hosp. Virgen Macarena
Seville, Spain
Hosp. Infanta Luisa
Seville, Spain
Hosp. Ntra. Sra. de Valme
Seville, Spain
Skanes universitetssjukhus
Malmö, Sweden
Karolinska Universitetssjukhuset Solna
Solna, Sweden
State Institution Institute of therapy named after L.T.Malaya AMS Ukraine
Kharkiv, Ukraine
Municipal Institution Regional hospital-center of emergency care and disasters medicine
Kharkiv, Ukraine
Medical Research and Practice Center Medbud of the Public Joint Stock Holding Company Kyivmiskbud
Kyiv, Ukraine
Kyiv Railway Clinical Hospital #2 Of Branch 'Health Center' Of The Company 'Ukrainian Railway'
Kyiv, Ukraine
SI National Scientific Center Institute of Cardiology of M.D. Strazhesko of NAMS of Ukraine
Kyiv, Ukraine
Municipal Non-Profit Enterprise of Kyiv Regional Council 'Kyiv regional Clinical Hospital'
Kyiv, Ukraine
ME Poltava Regional Clinical Hospital named after M.V. Sklifosovsky of Poltava Regional Consuil
Poltava, Ukraine
Municipal institution of Tepnopil Regional Council 'Ternopil University Hospital'
Ternopil, Ukraine
MNCE Zakarpatska Regional Clinical Hospital named after A Novak of Zakarpatska Regional Council
Uzhhorod, Ukraine
Health Clinic Limited Liability Company
Vinnytsia, Ukraine
Medical Center LLC 'Modern Clinic'
Zaporizhzhya, Ukraine