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Characterization of the microVAScular Dysfunction in Covid-19 ARDS
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The primary endpoint of this research is to establish that the alveolar dead space is significantly higher in patients with COVID-19 ARDS, compared to patients with non-COVID-19 ARDS. Secondarily, the investigators want to establish the prognostic value of the alveolar-dead space (measured iteratively) in patients with COVID-19 and non-COVID-19 ARDS, to establish the respective influences of the biological parameters of endothelial damage, of the biological parameters of coagulopathy, of the parameters set on the artificial ventilator on the value of the alveolar dead space; in ARDS patients with COVID-19 and non-COVID-19 ARDS, to establish the prognostic value of the laboratory parameters of endothelial damage and coagulopathy in patients with COVID-19 and non-COVID-19 ARDS.
Official title: Characterization of the microVAScular Dysfunction in COvid-19 ARDS
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
39
Start Date
2021-12-10
Completion Date
2023-03-06
Last Updated
2026-07-08
Healthy Volunteers
No
Interventions
alveolar dead-space quantification
measurement of alveolar dead-space based on volumetric capnography
Coagulation activation and impaired fibrinolysis explorations
blood sampling: * Fibrinolytic components * NETs components * Elastase-derived fragments of proteins of interest
Endothelial activation / endothelial senescence
circulating endothelial cells, E-selectin, endoglin, LVEF-A, LVEFR-2, Angiopoietin -1 and -2, cKit and SDF-1 Willebrand factor (activity, antigen, multimeric analysis )
Locations (1)
Hôpital européen Georges Pompidou
Paris, Paris, France