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Phase 1/2 Study of Avutometinib (VS-6766) + Sotorasib With or Without Defactinib in KRAS G12C NSCLC Patients
Sponsor: Verastem, Inc.
Summary
This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with sotorasib with or without defactinib in patients with KRAS G12C Non-Small Cell Lung Cancer (NSCLC) in patients who have been exposed to prior G12C inhibitor and those who have not been exposed to prior G12C inhibitor.
Official title: A Phase 1/2 Study of Avutometinib (VS-6766) in Combination With Sotorasib With or Without Defactinib in Patients With KRAS G12C Mutant Non-Small Cell Lung Cancer (NSCLC)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
153
Start Date
2022-04-12
Completion Date
2027-04
Last Updated
2026-01-12
Healthy Volunteers
No
Interventions
avutometinib and sotorasib
The RP2D of avutometinib + sotorasib determined in Part A will be used in Part B dose expansion
avutometinib and sotorasib and defactinib
The RP2D of avutometinib + sotorasib + defactinib determined in Part A will be used in Part B dose expansion
Locations (35)
Rocky Mountain Cancer Center, LLP
Boulder, Colorado, United States
Georgetown University Medical Center
Washington D.C., District of Columbia, United States
MedStar Washington Hospital Center, MedStar Georgetown Cancer Institute,
Washington D.C., District of Columbia, United States
Illinois Cancer Specialists
Arlington Heights, Illinois, United States
Maryland Oncology & Hematology, P.A.
Rockville, Maryland, United States
Dana Farber Cancer Institute
Boston, Massachusetts, United States
Henry Ford Health System
Detroit, Michigan, United States
Minnesota Oncology Hematology, P.A
Woodbury, Minnesota, United States
Washington University School of Medicine
St Louis, Missouri, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, United States
Ohio State University Brain and Spine Hospital
Columbus, Ohio, United States
Consultants in Medical Oncology & Hematology
Broomall, Pennsylvania, United States
Alliance Cancer Specialists,
Horsham, Pennsylvania, United States
Texas Oncology
Austin, Texas, United States
University of Texas Southwestern Medical Center
Dallas, Texas, United States
Texas Oncology - Fort Worth Cancer Center
Fort Worth, Texas, United States
Texas Oncology
Longview, Texas, United States
Oncology and Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care
Blacksburg, Virginia, United States
Virginia Cancer Specialists, PC
Fairfax, Virginia, United States
Northwest Cancer Specialists
Vancouver, Washington, United States
University Hospital Gent
Ghent, Belgium
CHU de Liège
Liège, Belgium
CHRU of Lille
Lille, France
Hôpital Cochin
Paris, France
Hôpital Foch
Suresnes, France
Leids Universitair Medisch Centrum
Leiden, Netherlands
Erasmus MC
Rotterdam, Netherlands
Hospital Teresa Herrera (C.H.U.A.C)
A Coruña, Spain
Hospital General Universitario Gregorio Marañón
Madrid, Spain
Hospital Universitario Fundación Jiménez Díaz
Madrid, Spain
Hospital Universitario Virgen De La Victoria
Málaga, Spain
Hospital Universitario Virgen de la Macarena
Seville, Spain
University of Leicester
Leicester, United Kingdom
Royal Marsden Hospital
London, United Kingdom
Royal Marsden Hospital
Sutton, United Kingdom