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Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Breast Cancer
Sponsor: Abramson Cancer Center at Penn Medicine
Summary
This is an observational study for patients with breast cancer that will be treated with doxorubicin (Adriamycin) and/or trastuzumab (Herceptin). The study will help the investigators learn more about how these medications affect the heart and how those effects relate to patients' medical history and social determinants of health (such as race, gender identity, education, occupation, access to health services and economic resources). Patients on this study will have echocardiograms, blood draws, and answer questions about their symptoms and activity level. Patients will be followed on this study for up to 15 years.
Official title: Cardiotoxicity of Cancer Therapy 2: Mechanisms, Predictors, and Social Determinants of Health in Breast Cancer Patients Treated With Doxorubicin and/or Trastuzumab
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2021-10-21
Completion Date
2039-10
Last Updated
2025-11-06
Healthy Volunteers
No
Conditions
Interventions
Social Determinants of Health
The study will perform detailed phenotyping of Social Determinants of Health using the National Institute of Minority Health and Health Disparities PhenX SDOH toolkit at baseline.
Locations (1)
University of Pennsylvania
Philadelphia, Pennsylvania, United States