Clinical Research Directory

Inclusion Criteria: 1. Age \>21 years 2. Documented Coronary Artery Disease (CAD) defined as: * Myocardial Infarction at least 6 months prior; or * Stable ischemic heart disease (defined using one of the following tests suggestive of significant coronary artery disease): i. Positive exercise stress test ii. Positive Nuclear perfusion scan iii. Positive exercise or pharmacologic echocardiographic stress test iv. Positive magnetic resonance imaging coronary perfusion scan v. Coronary computed tomographic angiography Angiogram with stenosis ≥ 70% (or left main coronary artery ≥ 50%) or significant function disease based or positive fractional flow reserve testing by CT (FFRCT); vi. Invasive coronary angiography with ≥ 70% (or left main coronary artery ≥ 50%) or significant function disease based or positive fractional flow reserve testing (FFR) or instant wave free ratio (IFR), * Previous Percutaneous Coronary Intervention (PCI, at least 6 months prior if revascularization is performed for an MI); or * Previous Coronary Artery Bypass Grafting (CABG, at least 6 months prior if revascularization is performed for an MI) 3. Able and willing to provide informed consent Exclusion Criteria: 1. Left Ventricular Ejection Fraction \< 40% or current hospitalization for heart failure 2. Myocardial infarction \<6 months prior to randomization 3. Indication for β-blocker as determined by the treating physician (such as atrial or ventricular arrhythmias or ongoing angina not controlled by another agent) 4. Uncontrolled hypertension or uncontrolled angina symptoms (per the Investigator's discretion) 5. Non-compliance with medical therapy 6. Life expectancy \<1 year 7. Participation in another trial related to β-blockers or other anti-anginal drugs